9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Forrest City | 1 | 12,181 | 12,973 | -1.29% | 602 | 20 | City |
| Hughes | 2 | 958 | 1,051 | -1.94% | 423 | 2 | City |
| Madison | 3 | 706 | 761 | -1.53% | 284 | 2 | City |
| Palestine | 4 | 465 | 504 | -1.69% | 137 | 3 | City |
| Caldwell | 5 | 415 | 445 | -1.43% | 130 | 3 | Town |
| Colt | 6 | 278 | 297 | -1.42% | 221 | 1 | City |
| Wheatley | 7 | 258 | 277 | -1.53% | 84 | 3 | City |
| Widener | 8 | 197 | 211 | -1.5% | 361 | 1 | Town |
| Goodwin | 9 | 151 | 181 | 7.09% | 33 | 5 | CDP |
Forrest City is the largest city in St. Francis County, with a population of 12,181.
Goodwin is the smallest city in St. Francis County, with a population of 151.
There are 9 cities in St. Francis County, Arkansas.