10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grand Junction | 1 | 71,752 | 65,759 | 1.7% | 1,766 | 41 | City |
| Clifton | 2 | 19,331 | 20,783 | -0.2% | 3,230 | 6 | CDP |
| Fruita | 3 | 14,034 | 13,424 | 0.88% | 1,752 | 8 | City |
| Redlands | 4 | 8,971 | 8,863 | 0.21% | 696 | 13 | CDP |
| Fruitvale | 5 | 8,109 | 8,352 | 0.36% | 2,836 | 3 | CDP |
| Orchard Mesa | 6 | 7,257 | 6,484 | 0.39% | 1,979 | 4 | CDP |
| Palisade | 7 | 2,609 | 2,562 | 0.35% | 2,196 | 1 | Town |
| Loma | 8 | 1,528 | 1,571 | 1.06% | 140 | 11 | CDP |
| De Beque | 9 | 474 | 491 | -0.84% | 171 | 3 | Town |
| Collbran | 10 | 363 | 371 | -0.55% | 651 | 1 | Town |
Grand Junction is the largest city in Mesa County, with a population of 71,752.
Collbran is the smallest city in Mesa County, with a population of 363.
There are 10 cities in Mesa County, Colorado.