12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Palatka | 1 | 10,965 | 10,463 | 0.9% | 1,113 | 10 | City |
| Palatka | 2 | 10,965 | 10,472 | 0.9% | 1,113 | 10 | City |
| Flagler Estates | 3 | 3,706 | 3,348 | 0.87% | 313 | 12 | CDP |
| Crescent City | 4 | 1,739 | 1,659 | 0.87% | 842 | 2 | City |
| Crescent City | 5 | 1,739 | 1,661 | 0.87% | 842 | 2 | City |
| Interlachen | 6 | 1,527 | 1,425 | 1.26% | 251 | 6 | Town |
| Interlachen | 7 | 1,527 | 1,429 | 1.26% | 251 | 6 | Town |
| East Palatka | 8 | 1,418 | 1,625 | -1.12% | 446 | 3 | CDP |
| Pomona Park | 9 | 834 | 781 | 1.21% | 274 | 3 | Town |
| Pomona Park | 10 | 834 | 782 | 1.21% | 274 | 3 | Town |
| Welaka | 11 | 773 | 721 | 1.31% | 521 | 1 | Town |
| Welaka | 12 | 773 | 723 | 1.31% | 521 | 1 | Town |
Palatka is the largest city in Putnam County, with a population of 10,965.
Welaka is the smallest city in Putnam County, with a population of 773.
There are 12 cities in Putnam County, Florida.