11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Centerville | 1 | 5,329 | 5,408 | -0.3% | 1,102 | 5 | City |
| Moravia | 2 | 622 | 637 | -0.48% | 529 | 1 | City |
| Moulton | 3 | 593 | 607 | -0.5% | 595 | 1 | City |
| Mystic | 4 | 316 | 323 | -0.63% | 107 | 3 | City |
| Cincinnati | 5 | 278 | 285 | -0.71% | 158 | 2 | City |
| Exline | 6 | 156 | 160 | -0.64% | 157 | 1 | City |
| Unionville | 7 | 73 | 75 | -1.35% | 97 | 1 | City |
| Numa | 8 | 68 | 70 | -1.45% | 154 | 0 | City |
| Plano | 9 | 56 | 58 | -1.75% | 100 | 1 | City |
| Rathbun | 10 | 43 | 45 | -2.27% | 201 | 0 | City |
| Udell | 11 | 30 | 32 | -3.23% | 107 | 0 | City |
Centerville is the largest city in Appanoose County, with a population of 5,329.
Udell is the smallest city in Appanoose County, with a population of 30.
There are 11 cities in Appanoose County, Iowa.