48 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Baxter Springs | 1 | 3,834 | 3,892 | -0.26% | 1,218 | 3 | City |
| Baxter Springs | 2 | 3,834 | 3,882 | -0.26% | 1,218 | 3 | City |
| Columbus | 3 | 2,868 | 2,926 | -0.35% | 1,179 | 2 | City |
| Columbus | 4 | 2,868 | 2,915 | -0.35% | 1,179 | 2 | City |
| Galena | 5 | 2,769 | 2,762 | 0.07% | 602 | 5 | City |
| Galena | 6 | 2,769 | 2,756 | 0.07% | 602 | 5 | City |
| Garden | 7 | 2,721 | 2,752 | 0.15% | 94 | 29 | Township |
| Garden | 8 | 2,721 | 2,744 | 0.15% | 94 | 29 | Township |
| Spring Valley | 9 | 1,008 | 1,021 | 0.3% | 21 | 47 | Township |
| Spring Valley | 10 | 1,008 | 1,018 | 0.3% | 21 | 47 | Township |
| Riverton | 11 | 679 | 893 | -2.44% | 302 | 2 | CDP |
| Lowell | 12 | 670 | 677 | 0.3% | 52 | 13 | Township |
| Lowell | 13 | 670 | 675 | 0.3% | 52 | 13 | Township |
| Ross | 14 | 622 | 627 | 0% | 12 | 54 | Township |
| Ross | 15 | 622 | 626 | 0% | 12 | 54 | Township |
| Crawford | 16 | 592 | 598 | 0.34% | 16 | 36 | Township |
| Crawford | 17 | 592 | 596 | 0.34% | 16 | 36 | Township |
| Weir | 18 | 570 | 572 | 0% | 501 | 1 | City |
| Weir | 19 | 570 | 570 | 0% | 501 | 1 | City |
| Pleasant View | 20 | 559 | 568 | 0.18% | 11 | 52 | Township |
| Pleasant View | 21 | 559 | 566 | 0.18% | 11 | 52 | Township |
| Salamanca | 22 | 462 | 474 | -0.22% | 13 | 34 | Township |
| Salamanca | 23 | 462 | 473 | -0.22% | 13 | 34 | Township |
| Chicopee | 24 | 383 | 533 | -0.52% | 121 | 3 | CDP |
| McCune | 25 | 374 | 370 | 0% | 1,176 | 0 | City |
| McCune | 26 | 374 | 372 | 0% | 1,176 | 0 | City |
| Scammon | 27 | 367 | 373 | -0.27% | 585 | 1 | City |
| Scammon | 28 | 367 | 372 | -0.27% | 585 | 1 | City |
| Lowell | 29 | 328 | 228 | 0.92% | 1,045 | 0 | CDP |
| Lyon | 30 | 319 | 324 | 0% | 6 | 50 | Township |
| Lyon | 31 | 319 | 323 | 0% | 6 | 50 | Township |
| Lola | 32 | 295 | 302 | -0.34% | 7 | 44 | Township |
| Lola | 33 | 295 | 301 | -0.34% | 7 | 44 | Township |
| Neosho | 34 | 244 | 244 | 0.41% | 4 | 61 | Township |
| Neosho | 35 | 244 | 243 | 0.41% | 4 | 61 | Township |
| Mineral | 36 | 211 | 217 | 0% | 7 | 31 | Township |
| Mineral | 37 | 211 | 216 | 0% | 7 | 31 | Township |
| Sheridan | 38 | 207 | 204 | 0.98% | 3 | 67 | Township |
| Sheridan | 39 | 207 | 203 | 0.98% | 3 | 67 | Township |
| West Mineral | 40 | 146 | 149 | -0.68% | 433 | 0 | City |
| West Mineral | 41 | 146 | 149 | -0.68% | 433 | 0 | City |
| Yale | 42 | 95 | 66 | 6.74% | 96 | 1 | CDP |
| Crestline | 43 | 75 | 34 | 7.14% | 42 | 2 | CDP |
| Roseland | 44 | 74 | 73 | 0% | 101 | 1 | City |
| Roseland | 45 | 74 | 73 | 0% | 101 | 1 | City |
| Hallowell | 46 | 70 | 49 | 7.69% | 81 | 1 | CDP |
| Labette | 47 | 54 | 56 | -1.82% | 241 | 0 | City |
| Labette | 48 | 54 | 56 | -1.82% | 241 | 0 | City |
Baxter Springs is the largest city in Cherokee County, with a population of 3,834.
Labette is the smallest city in Cherokee County, with a population of 54.
There are 48 cities in Cherokee County, Kansas.