20 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wano | 1 | 1,768 | 1,745 | 0.4% | 5 | 362 | Township |
| Wano | 2 | 1,768 | 1,743 | 0.4% | 5 | 362 | Township |
| St. Francis | 3 | 1,285 | 1,270 | 0.23% | 1,499 | 1 | City |
| St. Francis | 4 | 1,285 | 1,268 | 0.23% | 1,499 | 1 | City |
| Bird City | 5 | 690 | 673 | 0.58% | 2 | 341 | Township |
| Bird City | 6 | 690 | 673 | 0.58% | 2 | 341 | Township |
| Bird City | 7 | 450 | 437 | 0.45% | 199 | 2 | City |
| Bird City | 8 | 450 | 437 | 0.45% | 199 | 2 | City |
| McDonald | 9 | 114 | 117 | -0.87% | 521 | 0 | City |
| McDonald | 10 | 114 | 117 | -0.87% | 521 | 0 | City |
| Cleveland Run | 11 | 55 | 54 | 0% | 1 | 72 | Township |
| Cleveland Run | 12 | 55 | 54 | 0% | 1 | 72 | Township |
| Orlando | 13 | 53 | 52 | 0% | 1 | 36 | Township |
| Orlando | 14 | 53 | 52 | 0% | 1 | 36 | Township |
| Benkelman | 15 | 46 | 44 | 2.22% | 1 | 72 | Township |
| Benkelman | 16 | 46 | 44 | 2.22% | 1 | 72 | Township |
| Calhoun | 17 | 32 | 32 | 0% | 0.00 | 89 | Township |
| Calhoun | 18 | 32 | 32 | 0% | 0.00 | 89 | Township |
| Jaqua | 19 | 14 | 14 | 0% | 0.00 | 48 | Township |
| Jaqua | 20 | 14 | 14 | 0% | 0.00 | 48 | Township |
Wano is the largest city in Cheyenne County, with a population of 1,768.
Jaqua is the smallest city in Cheyenne County, with a population of 14.
There are 20 cities in Cheyenne County, Kansas.