14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Coldwater | 1 | 921 | 908 | 1.21% | 2 | 424 | Township |
| Coldwater | 2 | 921 | 904 | 1.21% | 2 | 424 | Township |
| Coldwater | 3 | 688 | 685 | 0.15% | 269 | 3 | City |
| Coldwater | 4 | 688 | 682 | 0.15% | 269 | 3 | City |
| Protection | 5 | 659 | 649 | 1.23% | 4 | 173 | Township |
| Protection | 6 | 659 | 646 | 1.23% | 4 | 173 | Township |
| Protection | 7 | 495 | 494 | 0% | 534 | 1 | City |
| Protection | 8 | 495 | 492 | 0% | 534 | 1 | City |
| Avilla | 9 | 67 | 65 | 1.52% | 1 | 119 | Township |
| Avilla | 10 | 67 | 65 | 1.52% | 1 | 119 | Township |
| Powell | 11 | 67 | 67 | 0% | 1 | 72 | Township |
| Powell | 12 | 67 | 67 | 0% | 1 | 72 | Township |
| Wilmore | 13 | 34 | 34 | 0% | 192 | 0 | City |
| Wilmore | 14 | 34 | 34 | 0% | 192 | 0 | City |
Coldwater is the largest city in Comanche County, with a population of 921.
Wilmore is the smallest city in Comanche County, with a population of 34.
There are 14 cities in Comanche County, Kansas.