22 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Lawrence | 1 | 97,854 | 94,933 | 0.6% | 2,857 | 34 | City |
| Lawrence | 2 | 97,854 | 94,939 | 0.6% | 2,857 | 34 | City |
| Eudora | 3 | 8,006 | 7,730 | 0.86% | 164 | 49 | Township |
| Eudora | 4 | 8,006 | 7,729 | 0.86% | 164 | 49 | Township |
| Palmyra | 5 | 7,972 | 7,610 | 0.92% | 98 | 81 | Township |
| Palmyra | 6 | 7,972 | 7,608 | 0.92% | 98 | 81 | Township |
| Eudora | 7 | 6,601 | 6,417 | 0.56% | 2,181 | 3 | City |
| Eudora | 8 | 6,601 | 6,415 | 0.56% | 2,181 | 3 | City |
| Baldwin City | 9 | 5,026 | 4,823 | 0.82% | 1,770 | 3 | City |
| Baldwin City | 10 | 5,026 | 4,818 | 0.82% | 1,770 | 3 | City |
| Willow Springs | 11 | 1,603 | 1,509 | 1.33% | 30 | 54 | Township |
| Willow Springs | 12 | 1,603 | 1,512 | 1.33% | 30 | 54 | Township |
| Kanwaka | 13 | 1,510 | 1,432 | 1% | 36 | 42 | Township |
| Kanwaka | 14 | 1,510 | 1,432 | 1% | 36 | 42 | Township |
| Clinton | 15 | 659 | 619 | 1.54% | 21 | 31 | Township |
| Clinton | 16 | 659 | 620 | 1.54% | 21 | 31 | Township |
| Grant | 17 | 398 | 378 | 1.02% | 25 | 16 | Township |
| Grant | 18 | 398 | 377 | 1.02% | 25 | 16 | Township |
| Lawrence | 19 | 123 | 133 | -3.15% | 3 | 36 | Township |
| Lawrence | 20 | 123 | 132 | -3.15% | 3 | 36 | Township |
| Lawrence | 21 | 22 | 24 | -4.35% | 1 | 35 | Township |
| Lawrence | 22 | 22 | 24 | -4.35% | 1 | 35 | Township |
Lawrence is the largest city in Douglas County, with a population of 97,854.
Lawrence is the smallest city in Douglas County, with a population of 22.
There are 22 cities in Douglas County, Kansas.