14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Opelousas | 1 | 15,131 | 15,778 | -0.85% | 1,564 | 10 | City |
| Eunice | 2 | 9,010 | 9,387 | -0.83% | 1,754 | 5 | City |
| Sunset | 3 | 3,161 | 2,978 | 1.18% | 980 | 3 | Town |
| Port Barre | 4 | 1,746 | 1,753 | -0.06% | 1,620 | 1 | Town |
| Arnaudville | 5 | 999 | 999 | 0% | 1,439 | 1 | Town |
| Lawtell | 6 | 947 | 737 | -1.76% | 228 | 4 | CDP |
| Leonville | 7 | 881 | 868 | 0.34% | 323 | 3 | Town |
| Krotz Springs | 8 | 879 | 899 | -0.45% | 509 | 2 | Town |
| Grand Coteau | 9 | 757 | 772 | -0.39% | 312 | 2 | Town |
| Melville | 10 | 743 | 758 | -0.4% | 592 | 1 | Town |
| Washington | 11 | 708 | 742 | -0.98% | 856 | 1 | Town |
| Cankton | 12 | 580 | 579 | 0% | 284 | 2 | Village |
| Morrow | 13 | 194 | 188 | 7.18% | 182 | 1 | CDP |
| Palmetto | 14 | 99 | 94 | 1.02% | 112 | 1 | Village |
Opelousas is the largest city in St. Landry Parish, with a population of 15,131.
Palmetto is the smallest city in St. Landry Parish, with a population of 99.
There are 14 cities in St. Landry Parish, Louisiana.