8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bruce | 1 | 1,601 | 1,700 | -1.23% | 657 | 2 | Town |
| Calhoun City | 2 | 1,462 | 1,521 | -0.81% | 620 | 2 | Town |
| Vardaman | 3 | 1,057 | 1,110 | -1.03% | 779 | 1 | Town |
| Derma | 4 | 911 | 960 | -1.09% | 514 | 2 | Town |
| New Houlka | 5 | 680 | 697 | -0.58% | 554 | 1 | Town |
| Pittsboro | 6 | 155 | 162 | -1.27% | 158 | 1 | Village |
| Big Creek | 7 | 125 | 132 | -1.57% | 110 | 1 | Village |
| Slate Springs | 8 | 96 | 103 | -2.04% | 68 | 1 | Village |
Bruce is the largest city in Calhoun County, with a population of 1,601.
Slate Springs is the smallest city in Calhoun County, with a population of 96.
There are 8 cities in Calhoun County, Mississippi.