7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Durant | 1 | 1,890 | 2,207 | -3.23% | 844 | 2.24 | City |
| Tchula | 2 | 1,619 | 1,646 | -0.31% | 1,150 | 1.41 | Town |
| Lexington | 3 | 1,353 | 1,588 | -3.36% | 560 | 2.42 | City |
| Goodman | 4 | 1,133 | 1,253 | -2.07% | 1,378 | 0.82 | Town |
| Pickens | 5 | 785 | 914 | -3.21% | 615 | 1.28 | Town |
| Cruger | 6 | 232 | 267 | -2.93% | 241 | 0.96 | Town |
| West | 7 | 126 | 151 | -3.82% | 226 | 0.56 | Town |
Durant is the largest city in Holmes County, with a population of 1,890.
West is the smallest city in Holmes County.
There are 7 cities in Holmes County, Mississippi.