5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Greenwood | 1 | 13,374 | 14,637 | -1.86% | 1,084 | 12 | City |
| Itta Bena | 2 | 1,477 | 1,669 | -2.57% | 1,047 | 1 | City |
| Mississippi Valley State University | 3 | 874 | 1,029 | -2.35% | 487 | 2 | CDP |
| Schlater | 4 | 216 | 234 | -1.82% | 187 | 1 | Town |
| Morgan City | 5 | 188 | 207 | -2.08% | 320 | 1 | Town |
Greenwood is the largest city in Leflore County, with a population of 13,374.
Morgan City is the smallest city in Leflore County, with a population of 188.
There are 5 cities in Leflore County, Mississippi.