5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Charleston | 1 | 1,652 | 1,869 | -2.59% | 1,219 | 1 | City |
| Tutwiler | 2 | 1,425 | 2,474 | -12.84% | 515 | 3 | Town |
| Webb | 3 | 368 | 410 | -2.39% | 872 | 0 | Town |
| Sumner | 4 | 242 | 275 | -2.81% | 440 | 1 | Town |
| Glendora | 5 | 136 | 149 | -2.16% | 944 | 0 | Village |
Charleston is the largest city in Tallahatchie County, with a population of 1,652.
Glendora is the smallest city in Tallahatchie County, with a population of 136.
There are 5 cities in Tallahatchie County, Mississippi.