3 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Waynesboro | 1 | 4,491 | 4,569 | -0.36% | 354 | 13 | City |
| Clara | 2 | 644 | 551 | 2.55% | 165 | 4 | CDP |
| Buckatunna | 3 | 98 | 360 | -22.22% | 16 | 6 | CDP |
Waynesboro is the largest city in Wayne County, with a population of 4,491.
Buckatunna is the smallest city in Wayne County, with a population of 98.
There are 3 cities in Wayne County, Mississippi.