9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Kahoka | 1 | 1,975 | 1,965 | 0.1% | 1,244 | 2 | City |
| Wayland | 2 | 418 | 411 | 0.24% | 621 | 1 | City |
| Medill | 3 | 374 | 157 | 7.16% | 481 | 1 | CDP |
| Wyaconda | 4 | 208 | 213 | -0.48% | 323 | 1 | City |
| St. Francisville | 5 | 205 | 260 | 0.49% | 110 | 2 | CDP |
| Wayland | 6 | 153 | 150 | 0% | 3 | 45 | Township |
| Alexandria | 7 | 107 | 106 | 0% | 284 | 0 | City |
| Revere | 8 | 74 | 76 | -1.33% | 398 | 0 | Town |
| Luray | 9 | 71 | 71 | 0% | 351 | 0 | Village |
Kahoka is the largest city in Clark County, with a population of 1,975.
Luray is the smallest city in Clark County, with a population of 71.
There are 9 cities in Clark County, Missouri.