65 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wildwood | 1 | 35,005 | 35,418 | -0.22% | 525 | 67 | City |
| Wildwood | 2 | 35,005 | 35,390 | -0.22% | 525 | 67 | City |
| Washington | 3 | 15,726 | 14,648 | 1.32% | 1,580 | 10 | City |
| Washington | 4 | 15,726 | 14,699 | 1.32% | 1,580 | 10 | City |
| Union | 5 | 13,399 | 12,358 | 1.52% | 1,474 | 9 | City |
| Union | 6 | 13,399 | 12,393 | 1.52% | 1,474 | 9 | City |
| Ellisville | 7 | 10,452 | 9,997 | 0.9% | 2,395 | 4 | City |
| Ellisville | 8 | 10,452 | 9,984 | 0.9% | 2,395 | 4 | City |
| Pacific | 9 | 7,964 | 7,484 | 1.56% | 1,165 | 7 | City |
| Pacific | 10 | 7,964 | 7,351 | 1.56% | 1,165 | 7 | City |
| Sullivan | 11 | 6,929 | 6,901 | 0.06% | 846 | 8 | City |
| Sullivan | 12 | 6,929 | 6,908 | 0.06% | 846 | 8 | City |
| St. Clair | 13 | 4,727 | 4,832 | -0.44% | 983 | 5 | City |
| St. Clair | 14 | 4,727 | 4,831 | -0.44% | 983 | 5 | City |
| Union | 15 | 3,258 | 3,443 | -0.37% | 32 | 103 | Township |
| Union | 16 | 3,258 | 3,434 | -0.37% | 32 | 103 | Township |
| Villa Ridge | 17 | 3,055 | 3,179 | 0.93% | 622 | 5 | CDP |
| Clarkson Valley | 18 | 2,544 | 2,611 | -0.51% | 944 | 3 | City |
| Clarkson Valley | 19 | 2,544 | 2,608 | -0.51% | 944 | 3 | City |
| Gray Summit | 20 | 2,541 | 2,383 | -0.43% | 330 | 8 | CDP |
| New Haven | 21 | 2,393 | 2,419 | -0.25% | 745 | 3 | City |
| New Haven | 22 | 2,393 | 2,421 | -0.25% | 745 | 3 | City |
| Washington | 23 | 2,326 | 2,318 | 0.09% | 65 | 36 | Township |
| Washington | 24 | 2,326 | 2,314 | 0.09% | 65 | 36 | Township |
| Union | 25 | 2,178 | 2,153 | -0.18% | 60 | 36 | Township |
| Union | 26 | 2,178 | 2,154 | -0.18% | 60 | 36 | Township |
| Union | 27 | 2,029 | 2,144 | -2.31% | 45 | 45 | Township |
| Union | 28 | 2,029 | 2,148 | -2.31% | 45 | 45 | Township |
| Washington | 29 | 1,812 | 1,818 | -0.17% | 38 | 48 | Township |
| Washington | 30 | 1,812 | 1,813 | -0.17% | 38 | 48 | Township |
| Gerald | 31 | 1,354 | 1,374 | -0.37% | 916 | 1 | City |
| Gerald | 32 | 1,354 | 1,376 | -0.37% | 916 | 1 | City |
| LaBarque Creek | 33 | 1,112 | 1,165 | -2.63% | 63 | 18 | CDP |
| Lake St. Clair | 34 | 1,056 | 692 | 7.1% | 1,459 | 1 | CDP |
| Parkway | 35 | 638 | 658 | -0.62% | 1,357 | 0 | Village |
| Parkway | 36 | 638 | 658 | -0.62% | 1,357 | 0 | Village |
| Union | 37 | 508 | 508 | -0.2% | 14 | 36 | Township |
| Union | 38 | 508 | 507 | -0.2% | 14 | 36 | Township |
| Union | 39 | 399 | 430 | -1.48% | 8 | 47 | Township |
| Union | 40 | 399 | 429 | -1.48% | 8 | 47 | Township |
| Stanton | 41 | 395 | 249 | 7.05% | 121 | 3 | CDP |
| Union | 42 | 380 | 380 | -0.52% | 10 | 37 | Township |
| Union | 43 | 380 | 380 | -0.52% | 10 | 37 | Township |
| Washington | 44 | 367 | 380 | -1.34% | 6 | 57 | Township |
| Washington | 45 | 367 | 378 | -1.34% | 6 | 57 | Township |
| Berger | 46 | 269 | 268 | 0% | 857 | 0 | City |
| Berger | 47 | 269 | 268 | 0% | 857 | 0 | City |
| Washington | 48 | 266 | 287 | -1.48% | 6 | 47 | Township |
| Washington | 49 | 266 | 287 | -1.48% | 6 | 47 | Township |
| Lake Tekakwitha | 50 | 236 | 233 | 0% | 1,180 | 0 | Village |
| Lake Tekakwitha | 51 | 236 | 233 | 0% | 1,180 | 0 | Village |
| Washington | 52 | 162 | 164 | 0.62% | 4 | 36 | Township |
| Washington | 53 | 162 | 163 | 0.62% | 4 | 36 | Township |
| Leslie | 54 | 156 | 152 | 1.96% | 4 | 36 | Township |
| Leslie | 55 | 156 | 151 | 1.96% | 4 | 36 | Township |
| Leslie | 56 | 156 | 154 | 0% | 918 | 0 | Village |
| Leslie | 57 | 156 | 154 | 0% | 918 | 0 | Village |
| Washington | 58 | 153 | 153 | 0% | 7 | 21 | Township |
| Washington | 59 | 153 | 152 | 0% | 7 | 21 | Township |
| Washington | 60 | 148 | 146 | 0% | 4 | 36 | Township |
| Washington | 61 | 148 | 146 | 0% | 4 | 36 | Township |
| Washington | 62 | 92 | 91 | 0% | 3 | 36 | Township |
| Washington | 63 | 92 | 91 | 0% | 3 | 36 | Township |
| Charmwood | 64 | 16 | 16 | 0% | 114 | 0 | Town |
| Charmwood | 65 | 16 | 16 | 0% | 114 | 0 | Town |
Wildwood is the largest city in Franklin County, with a population of 35,005.
Charmwood is the smallest city in Franklin County, with a population of 16.
There are 65 cities in Franklin County, Missouri.