14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Ironton | 1 | 1,437 | 1,469 | -0.42% | 1,070 | 1 | City |
| Ironton | 2 | 1,437 | 1,466 | -0.42% | 1,070 | 1 | City |
| Pilot Knob | 3 | 685 | 674 | 0.29% | 766 | 1 | City |
| Pilot Knob | 4 | 685 | 672 | 0.29% | 766 | 1 | City |
| Viburnum | 5 | 656 | 667 | -0.3% | 382 | 2 | City |
| Viburnum | 6 | 656 | 666 | -0.3% | 382 | 2 | City |
| Iron Mountain Lake | 7 | 639 | 641 | -0.16% | 326 | 2 | City |
| Iron Mountain Lake | 8 | 639 | 641 | -0.16% | 326 | 2 | City |
| Arcadia | 9 | 604 | 618 | -0.49% | 730 | 1 | City |
| Arcadia | 10 | 604 | 617 | -0.49% | 730 | 1 | City |
| Annapolis | 11 | 244 | 250 | -0.41% | 652 | 0 | City |
| Annapolis | 12 | 244 | 249 | -0.41% | 652 | 0 | City |
| Des Arc | 13 | 128 | 130 | -0.78% | 604 | 0 | Village |
| Des Arc | 14 | 128 | 130 | -0.78% | 604 | 0 | Village |
Ironton is the largest city in Iron County, with a population of 1,437.
Des Arc is the smallest city in Iron County, with a population of 128.
There are 14 cities in Iron County, Missouri.