17 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Noel | 1 | 2,205 | 2,129 | 0.68% | 1,089 | 2 | City |
| Noel | 2 | 2,205 | 2,127 | 0.68% | 1,089 | 2 | City |
| Anderson | 3 | 2,101 | 2,041 | 0.57% | 924 | 2 | City |
| Anderson | 4 | 2,101 | 2,039 | 0.57% | 924 | 2 | City |
| Goodman | 5 | 1,331 | 1,202 | 1.99% | 1,003 | 1 | City |
| Goodman | 6 | 1,331 | 1,201 | 1.99% | 1,003 | 1 | City |
| Southwest City | 7 | 990 | 920 | 1.43% | 677 | 1 | Town |
| Southwest City | 8 | 990 | 919 | 1.43% | 677 | 1 | Town |
| Pineville | 9 | 855 | 793 | 1.42% | 260 | 3 | City |
| Pineville | 10 | 855 | 792 | 1.42% | 260 | 3 | City |
| Jane | 11 | 411 | 358 | 2.49% | 138 | 3 | Town |
| Jane | 12 | 411 | 358 | 2.49% | 138 | 3 | Town |
| Lanagan | 13 | 382 | 374 | 0.26% | 406 | 1 | Town |
| Lanagan | 14 | 382 | 374 | 0.26% | 406 | 1 | Town |
| Rocky Comfort | 15 | 194 | 96 | 7.18% | 350 | 1 | CDP |
| Ginger Blue | 16 | 35 | 34 | 0% | 134 | 0 | Village |
| Ginger Blue | 17 | 35 | 34 | 0% | 134 | 0 | Village |
Noel is the largest city in McDonald County, with a population of 2,205.
Ginger Blue is the smallest city in McDonald County, with a population of 35.
There are 17 cities in McDonald County, Missouri.