21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caruthersville | 1 | 5,077 | 5,565 | -1.8% | 984 | 5 | City |
| Caruthersville | 2 | 5,077 | 5,540 | -1.8% | 984 | 5 | City |
| Hayti | 3 | 2,222 | 2,489 | -2.24% | 968 | 2 | City |
| Hayti | 4 | 2,222 | 2,477 | -2.24% | 968 | 2 | City |
| Steele | 5 | 1,654 | 1,853 | -2.25% | 765 | 2 | City |
| Steele | 6 | 1,654 | 1,844 | -2.25% | 765 | 2 | City |
| Hayti Heights | 7 | 454 | 511 | -2.37% | 463 | 1 | City |
| Hayti Heights | 8 | 454 | 509 | -2.37% | 463 | 1 | City |
| Cooter | 9 | 312 | 346 | -2.19% | 1,058 | 0 | City |
| Cooter | 10 | 312 | 344 | -2.19% | 1,058 | 0 | City |
| Wardell | 11 | 275 | 310 | -2.48% | 975 | 0 | Town |
| Wardell | 12 | 275 | 308 | -2.48% | 975 | 0 | Town |
| Holland | 13 | 176 | 195 | -2.22% | 1,054 | 0 | Town |
| Holland | 14 | 176 | 194 | -2.22% | 1,054 | 0 | Town |
| Pascola | 15 | 79 | 87 | -2.47% | 494 | 0 | Village |
| Pascola | 16 | 79 | 87 | -2.47% | 494 | 0 | Village |
| Deering | 17 | 76 | 67 | 7.04% | 258 | 0 | CDP |
| Homestown | 18 | 67 | 75 | -2.9% | 545 | 0 | City |
| Homestown | 19 | 67 | 75 | -2.9% | 545 | 0 | City |
| Bragg City | 20 | 59 | 67 | -3.28% | 289 | 0 | Town |
| Bragg City | 21 | 59 | 67 | -3.28% | 289 | 0 | Town |
Caruthersville is the largest city in Pemiscot County, with a population of 5,077.
Bragg City is the smallest city in Pemiscot County, with a population of 59.
There are 21 cities in Pemiscot County, Missouri.