11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caruthersville | 1 | 5,077 | 5,540 | -1.8% | 984 | 5 | City |
| Hayti | 2 | 2,222 | 2,477 | -2.24% | 968 | 2 | City |
| Steele | 3 | 1,654 | 1,844 | -2.25% | 765 | 2 | City |
| Hayti Heights | 4 | 454 | 509 | -2.37% | 463 | 1 | City |
| Cooter | 5 | 312 | 344 | -2.19% | 1,058 | 0 | City |
| Wardell | 6 | 275 | 308 | -2.48% | 975 | 0 | Town |
| Holland | 7 | 176 | 194 | -2.22% | 1,054 | 0 | Town |
| Pascola | 8 | 79 | 87 | -2.47% | 494 | 0 | Village |
| Deering | 9 | 76 | 67 | 7.04% | 258 | 0 | CDP |
| Homestown | 10 | 67 | 75 | -2.9% | 545 | 0 | City |
| Bragg City | 11 | 59 | 67 | -3.28% | 289 | 0 | Town |
Caruthersville is the largest city in Pemiscot County, with a population of 5,077.
Bragg City is the smallest city in Pemiscot County, with a population of 59.
There are 11 cities in Pemiscot County, Missouri.