22 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Marshall | 1 | 13,790 | 13,794 | -0.01% | 1,362 | 10 | City |
| Marshall | 2 | 13,790 | 13,795 | -0.01% | 1,362 | 10 | City |
| Slater | 3 | 1,820 | 1,833 | -0.16% | 1,259 | 1 | City |
| Slater | 4 | 1,820 | 1,833 | -0.16% | 1,259 | 1 | City |
| Sweet Springs | 5 | 1,332 | 1,324 | 0.08% | 801 | 2 | City |
| Sweet Springs | 6 | 1,332 | 1,325 | 0.08% | 801 | 2 | City |
| Blackburn | 7 | 222 | 222 | 0% | 718 | 0 | City |
| Blackburn | 8 | 222 | 222 | 0% | 718 | 0 | City |
| Malta Bend | 9 | 188 | 191 | -0.53% | 743 | 0 | Town |
| Malta Bend | 10 | 188 | 191 | -0.53% | 743 | 0 | Town |
| Gilliam | 11 | 177 | 177 | 0% | 714 | 0 | City |
| Gilliam | 12 | 177 | 177 | 0% | 714 | 0 | City |
| Nelson | 13 | 154 | 154 | 0% | 468 | 0 | City |
| Nelson | 14 | 154 | 154 | 0% | 468 | 0 | City |
| Miami | 15 | 150 | 150 | 0% | 268 | 1 | City |
| Miami | 16 | 150 | 150 | 0% | 268 | 1 | City |
| Mount Leonard | 17 | 62 | 62 | 0% | 596 | 0 | Town |
| Mount Leonard | 18 | 62 | 62 | 0% | 596 | 0 | Town |
| Arrow Rock | 19 | 60 | 60 | 0% | 451 | 0 | Town |
| Arrow Rock | 20 | 60 | 60 | 0% | 451 | 0 | Town |
| Grand Pass | 21 | 50 | 50 | 0% | 459 | 0 | Village |
| Grand Pass | 22 | 50 | 50 | 0% | 459 | 0 | Village |
Marshall is the largest city in Saline County, with a population of 13,790.
Grand Pass is the smallest city in Saline County, with a population of 50.
There are 22 cities in Saline County, Missouri.