35 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Creighton | 1 | 1,105 | 1,149 | -0.81% | 913 | 1 | City |
| Bloomfield | 2 | 929 | 983 | -1.17% | 1,138 | 1 | City |
| Center | 3 | 782 | 743 | 0.13% | 23 | 34 | Township |
| Hill | 4 | 766 | 759 | 0% | 11 | 67 | Township |
| Crofton | 5 | 758 | 755 | 0% | 1,184 | 1 | City |
| Verdigre | 6 | 618 | 635 | -0.8% | 17 | 36 | Township |
| Wausa | 7 | 579 | 591 | -0.52% | 1,105 | 1 | Village |
| Verdigre | 8 | 531 | 545 | -0.56% | 969 | 1 | Village |
| Santee | 9 | 428 | 423 | 0.23% | 759 | 1 | Village |
| Niobrara | 10 | 412 | 416 | -0.24% | 18 | 22 | Township |
| Niobrara | 11 | 360 | 365 | -0.28% | 495 | 1 | Village |
| Eastern | 12 | 258 | 254 | 0.39% | 7 | 36 | Township |
| Creighton | 13 | 202 | 202 | 0% | 6 | 35 | Township |
| Center | 14 | 188 | 188 | 0% | 5 | 36 | Township |
| Morton | 15 | 167 | 165 | 0.6% | 5 | 35 | Township |
| North Frankfort | 16 | 166 | 166 | 0% | 51 | 3 | Township |
| Peoria | 17 | 141 | 143 | -0.7% | 4 | 36 | Township |
| Dolphin | 18 | 126 | 128 | -0.79% | 3 | 36 | Township |
| Addison | 19 | 123 | 125 | -0.81% | 3 | 36 | Township |
| Columbia | 20 | 115 | 116 | -0.86% | 3 | 36 | Township |
| Cleveland | 21 | 114 | 115 | -0.87% | 3 | 36 | Township |
| Jefferson | 22 | 107 | 108 | -0.93% | 3 | 36 | Township |
| Dowling | 23 | 106 | 107 | -0.93% | 3 | 36 | Township |
| Herrick | 24 | 90 | 90 | 0% | 5 | 19 | Township |
| Frankfort | 25 | 88 | 89 | -1.12% | 5 | 18 | Township |
| Walnut Grove | 26 | 84 | 82 | 1.2% | 2 | 53 | Township |
| Central | 27 | 80 | 81 | -1.23% | 2 | 36 | Township |
| Center | 28 | 70 | 74 | -1.41% | 667 | 0 | Village |
| Spade | 29 | 68 | 65 | 3.03% | 2 | 35 | Township |
| Sparta | 30 | 66 | 67 | -1.49% | 2 | 35 | Township |
| Logan | 31 | 62 | 61 | 1.64% | 2 | 36 | Township |
| Winnetoon | 32 | 53 | 53 | 0% | 183 | 0 | Village |
| Bohemia | 33 | 43 | 42 | 2.38% | 1 | 34 | Township |
| Verdel | 34 | 41 | 40 | 0% | 237 | 0 | Village |
| Lindy | 35 | 21 | 19 | 5% | 21 | 1 | CDP |
Creighton is the largest city in Knox County, with a population of 1,105.
Lindy is the smallest city in Knox County, with a population of 21.
There are 35 cities in Knox County, Nebraska.