25 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Columbus | 1 | 25,384 | 24,093 | 1.03% | 2,393 | 11 | City |
| Columbus | 2 | 3,402 | 3,304 | 1.04% | 68 | 50 | Township |
| Granville | 3 | 989 | 947 | 1.64% | 28 | 36 | Township |
| Shell Creek | 4 | 977 | 952 | 1.03% | 27 | 36 | Township |
| Humphrey | 5 | 891 | 855 | 0.79% | 1,717 | 1 | City |
| Butler | 6 | 622 | 605 | 1.14% | 20 | 31 | Township |
| Lost Creek | 7 | 521 | 510 | 0.97% | 14 | 36 | Township |
| St. Bernard | 8 | 519 | 497 | 1.37% | 15 | 36 | Township |
| Oconee | 9 | 508 | 497 | 0.99% | 20 | 25 | Township |
| Humphrey | 10 | 503 | 484 | 1.62% | 14 | 36 | Township |
| Bismark | 11 | 445 | 437 | 0.91% | 13 | 35 | Township |
| Duncan | 12 | 389 | 382 | 0.26% | 831 | 0 | Village |
| Creston | 13 | 382 | 374 | 1.06% | 11 | 36 | Township |
| Platte Center | 14 | 339 | 336 | 0% | 1,134 | 0 | Village |
| Grand Prairie | 15 | 338 | 332 | 0.9% | 9 | 36 | Township |
| Lindsay | 16 | 300 | 283 | 1.01% | 633 | 0 | Village |
| Monroe | 17 | 295 | 292 | 0% | 1,513 | 0 | Village |
| Burrows | 18 | 260 | 259 | 0% | 7 | 36 | Township |
| Sherman | 19 | 226 | 225 | 0% | 6 | 36 | Township |
| Walker | 20 | 205 | 202 | 0.99% | 4 | 54 | Township |
| Loup | 21 | 194 | 189 | 1.04% | 5 | 42 | Township |
| Creston | 22 | 176 | 175 | 0% | 850 | 0 | Village |
| Joliet | 23 | 131 | 128 | 0.77% | 4 | 36 | Township |
| Monroe | 24 | 126 | 123 | 0.8% | 4 | 34 | Township |
| Woodville | 25 | 125 | 122 | 0.81% | 4 | 35 | Township |
Columbus is the largest city in Platte County, with a population of 25,384.
Woodville is the smallest city in Platte County, with a population of 125.
There are 25 cities in Platte County, Nebraska.