8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Santa Rosa | 1 | 2,817 | 2,859 | -0.25% | 564 | 5 | City |
| Santa Rosa | 2 | 2,817 | 2,852 | -0.25% | 564 | 5 | City |
| Tecolotito | 3 | 562 | 549 | 4.07% | 782 | 1 | CDP |
| Puerto Luna | 4 | 453 | 226 | 4.62% | 32 | 14 | CDP |
| Vaughn | 5 | 274 | 280 | -0.36% | 49 | 6 | Town |
| Vaughn | 6 | 274 | 279 | -0.36% | 49 | 6 | Town |
| Anton Chico | 7 | 188 | 120 | 0% | 105 | 2 | CDP |
| Pastura | 8 | 4 | 3 | 0% | 12 | 0 | CDP |
Santa Rosa is the largest city in Guadalupe County, with a population of 2,817.
Pastura is the smallest city in Guadalupe County, with a population of 4.
There are 8 cities in Guadalupe County, New Mexico.