4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Henderson | 1 | 14,743 | 15,060 | -0.43% | 1,710 | 9 | City |
| South Henderson | 2 | 1,180 | 1,055 | -0.25% | 655 | 2 | CDP |
| Kittrell | 3 | 124 | 126 | -0.8% | 596 | 0 | Town |
| Middleburg | 4 | 103 | 103 | 0% | 131 | 1 | Town |
Henderson is the largest city in Vance County, with a population of 14,743.
Middleburg is the smallest city in Vance County, with a population of 103.
There are 4 cities in Vance County, North Carolina.