4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Gaffney | 1 | 12,498 | 12,738 | -0.38% | 1,393 | 9 | City |
| East Gaffney | 2 | 2,944 | 3,043 | -0.3% | 974 | 3 | CDP |
| Blacksburg | 3 | 1,970 | 1,888 | 0.82% | 1,053 | 2 | Town |
| Central Pacolet | 4 | 242 | 209 | 2.54% | 1,025 | 0 | Town |
Gaffney is the largest city in Cherokee County, with a population of 12,498.
Central Pacolet is the smallest city in Cherokee County, with a population of 242.
There are 4 cities in Cherokee County, South Carolina.