11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Cheraw | 1 | 4,932 | 5,000 | -0.28% | 828 | 6 | Town |
| North Hartsville | 2 | 3,264 | 1,972 | 0.03% | 721 | 5 | CDP |
| Pageland | 3 | 2,535 | 2,470 | 0.52% | 522 | 5 | Town |
| Chesterfield | 4 | 1,355 | 1,335 | 0.3% | 332 | 4 | Town |
| McBee | 5 | 818 | 786 | 0.74% | 623 | 1 | Town |
| Pine Ridge | 6 | 800 | 704 | 7.1% | 353 | 2 | CDP |
| Jefferson | 7 | 792 | 772 | 0.51% | 440 | 2 | Town |
| Cash | 8 | 521 | 298 | 7.2% | 342 | 2 | CDP |
| Ruby | 9 | 324 | 313 | 0.62% | 131 | 2 | Town |
| Patrick | 10 | 288 | 278 | 0.7% | 300 | 1 | Town |
| Mount Croghan | 11 | 135 | 135 | 0% | 178 | 1 | Town |
Cheraw is the largest city in Chesterfield County, with a population of 4,932.
Mount Croghan is the smallest city in Chesterfield County, with a population of 135.
There are 11 cities in Chesterfield County, South Carolina.