10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fort Mill | 1 | 39,004 | 25,204 | 7.62% | 1,979 | 20 | Town |
| Lancaster | 2 | 9,614 | 8,523 | 2.32% | 1,352 | 7 | City |
| Springdale | 3 | 2,582 | 2,878 | 0.04% | 611 | 4 | CDP |
| Kershaw | 4 | 2,080 | 1,748 | 3.28% | 1,120 | 2 | Town |
| Irwin | 5 | 1,984 | 1,308 | 2.01% | 665 | 3 | CDP |
| Van Wyck | 6 | 1,077 | 884 | 3.66% | 104 | 10 | Town |
| Heath Springs | 7 | 878 | 746 | 3.05% | 540 | 2 | Town |
| Unity | 8 | 791 | 641 | 7.18% | 374 | 2 | CDP |
| Buford | 9 | 654 | 708 | 7.21% | 287 | 2 | CDP |
| Tradesville | 10 | 84 | 90 | 7.69% | 42 | 2 | CDP |
Fort Mill is the largest city in Lancaster County, with a population of 39,004.
Tradesville is the smallest city in Lancaster County, with a population of 84.
There are 10 cities in Lancaster County, South Carolina.