8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bishopville | 1 | 2,851 | 2,993 | -1.01% | 1,220 | 2 | City |
| Stateburg | 2 | 1,829 | 1,912 | 1.67% | 393 | 5 | CDP |
| Oakland | 3 | 889 | 1,265 | -2.52% | 1,307 | 1 | CDP |
| Elliott | 4 | 698 | 608 | 7.22% | 376 | 2 | CDP |
| East Sumter | 5 | 651 | 1,208 | -6.6% | 196 | 3 | CDP |
| Oswego | 6 | 440 | 197 | 7.06% | 365 | 1 | CDP |
| Lynchburg | 7 | 306 | 321 | -0.97% | 270 | 1 | Town |
| Shiloh | 8 | 190 | 210 | -1.04% | 19 | 10 | CDP |
Bishopville is the largest city in Lee County, with a population of 2,851.
Shiloh is the smallest city in Lee County, with a population of 190.
There are 8 cities in Lee County, South Carolina.