19 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Lexington | 1 | 25,779 | 23,653 | 1.68% | 2,154 | 12 | Town |
| St. Andrews | 2 | 22,263 | 21,355 | 0.53% | 3,624 | 6 | CDP |
| West Columbia | 3 | 18,643 | 17,516 | 1.22% | 1,989 | 9 | City |
| Seven Oaks | 4 | 15,997 | 16,743 | 0.36% | 2,091 | 8 | CDP |
| Cayce | 5 | 13,617 | 13,756 | -0.21% | 807 | 17 | City |
| Oak Grove | 6 | 11,658 | 12,040 | 0.79% | 1,538 | 8 | CDP |
| Red Bank | 7 | 10,776 | 9,971 | 0.73% | 860 | 13 | CDP |
| White Knoll | 8 | 8,981 | 7,476 | 7.15% | 1,468 | 6 | CDP |
| Lake Murray Richland | 9 | 7,272 | 6,672 | 1.68% | 1,311 | 6 | CDP |
| Springdale | 10 | 2,760 | 2,740 | 0.15% | 1,021 | 3 | Town |
| South Congaree | 11 | 2,394 | 2,384 | 0.08% | 728 | 3 | Town |
| Chapin | 12 | 1,963 | 1,816 | 1.5% | 991 | 2 | Town |
| Gaston | 13 | 1,649 | 1,606 | 0.49% | 310 | 5 | Town |
| Edmund | 14 | 1,436 | 930 | 7.16% | 210 | 7 | CDP |
| Swansea | 15 | 782 | 727 | 1.43% | 375 | 2 | Town |
| Fairview Crossroads | 16 | 735 | 665 | 7.14% | 129 | 6 | CDP |
| Gilbert | 17 | 628 | 577 | 1.62% | 232 | 3 | Town |
| Pelion | 18 | 621 | 628 | -0.32% | 169 | 4 | Town |
| Summit | 19 | 469 | 423 | 1.96% | 315 | 1 | Town |
Lexington is the largest city in Lexington County, with a population of 25,779.
Summit is the smallest city in Lexington County, with a population of 469.
There are 19 cities in Lexington County, South Carolina.