24 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chamberlain | 1 | 2,448 | 2,472 | -0.2% | 547 | 4 | City |
| Kimball | 2 | 574 | 568 | 0.17% | 167 | 3 | City |
| Wilbur | 3 | 260 | 250 | 1.56% | 7 | 36 | Township |
| Pukwana | 4 | 236 | 233 | 0% | 308 | 1 | Town |
| Chamberlain | 5 | 231 | 237 | -2.12% | 12 | 20 | Township |
| Torrey Lake | 6 | 217 | 222 | -1.81% | 6 | 36 | Township |
| Brule | 7 | 163 | 163 | -0.61% | 4 | 42 | Township |
| Pukwana | 8 | 144 | 144 | -0.69% | 4 | 35 | Township |
| West Point | 9 | 107 | 107 | -1.83% | 2 | 47 | Township |
| Ola | 10 | 97 | 99 | -2.02% | 3 | 36 | Township |
| Cleveland | 11 | 88 | 88 | -1.12% | 2 | 37 | Township |
| Red Lake | 12 | 80 | 78 | -1.23% | 3 | 30 | Township |
| Union | 13 | 73 | 73 | -1.35% | 2 | 36 | Township |
| Waldro | 14 | 72 | 72 | -1.37% | 2 | 37 | Township |
| Richland | 15 | 53 | 53 | -1.85% | 1 | 36 | Township |
| Kimball | 16 | 51 | 51 | -1.92% | 2 | 32 | Township |
| Smith | 17 | 47 | 46 | 0% | 1 | 36 | Township |
| America | 18 | 46 | 45 | 0% | 1 | 42 | Township |
| Eagle | 19 | 42 | 41 | 0% | 1 | 35 | Township |
| Pleasant Grove | 20 | 39 | 37 | 2.63% | 1 | 35 | Township |
| Lyon | 21 | 35 | 33 | 2.94% | 1 | 35 | Township |
| Highland | 22 | 32 | 31 | 0% | 1 | 36 | Township |
| Plainfield | 23 | 31 | 33 | -3.13% | 1 | 35 | Township |
| Plummer | 24 | 15 | 15 | 0% | 0.00 | 36 | Township |
Chamberlain is the largest city in Brule County, with a population of 2,448.
Plummer is the smallest city in Brule County, with a population of 15.
There are 24 cities in Brule County, South Dakota.