17 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Big Stone Gap | 1 | 5,048 | 5,251 | -0.77% | 1,052 | 5 | Town |
| Big Stone Gap | 2 | 5,048 | 5,243 | -0.77% | 1,052 | 5 | Town |
| Wise | 3 | 2,843 | 2,978 | -0.91% | 936 | 3 | Town |
| Wise | 4 | 2,843 | 2,972 | -0.91% | 936 | 3 | Town |
| Coeburn | 5 | 1,543 | 1,609 | -0.84% | 791 | 2 | Town |
| Coeburn | 6 | 1,543 | 1,607 | -0.84% | 791 | 2 | Town |
| Appalachia | 7 | 1,361 | 1,440 | -1.09% | 395 | 3 | Town |
| Appalachia | 8 | 1,361 | 1,436 | -1.09% | 395 | 3 | Town |
| East Stone Gap | 9 | 1,035 | 858 | 7.14% | 1,927 | 1 | CDP |
| Pound | 10 | 832 | 871 | -0.95% | 319 | 3 | Town |
| Pound | 11 | 832 | 870 | -0.95% | 319 | 3 | Town |
| St. Paul | 12 | 828 | 863 | -0.84% | 601 | 1 | Town |
| St. Paul | 13 | 828 | 862 | -0.84% | 601 | 1 | Town |
| The University Virginia's College Wise | 14 | 812 | 684 | 7.12% | 1,888 | 0 | CDP |
| Stonega | 15 | 188 | 206 | 7.43% | 302 | 1 | CDP |
| Osaka | 16 | 128 | 74 | 7.56% | 297 | 0 | CDP |
| Dunbar | 17 | 54 | 96 | 8% | 2,348 | 0 | CDP |
Big Stone Gap is the largest city in Wise County, with a population of 5,048.
Dunbar is the smallest city in Wise County, with a population of 54.
There are 17 cities in Wise County, Virginia.