8 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Olive Branch | DeSoto County | 47,565 |
| Oxford | Lafayette County | 27,124 |
| Ocean Springs | Jackson County | 19,100 |
| Okolona | Chickasaw County | 2,394 |
| Oak Grove | Covington County | 1,961 |
| Oakland | Yalobusha County | 457 |
| Osyka | Pike County | 356 |
| Ovett | Jones County | 134 |