5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Belzoni | 1 | 1,704 | 1,883 | -2.07% | 1,672 | 1 | City |
| Isola | 2 | 570 | 634 | -2.23% | 771 | 1 | Town |
| Louise | 3 | 163 | 180 | -2.4% | 921 | 0 | Town |
| Silver City | 4 | 152 | 226 | -8.98% | 252 | 1 | Town |
| Eden | 5 | 134 | 132 | 0% | 283 | 0 | Village |
Belzoni is the largest city in Humphreys County, with a population of 1,704.
Eden is the smallest city in Humphreys County, with a population of 134.
There are 5 cities in Humphreys County, Mississippi.