Knob Lick
- County:
- St. Francois County
- County Seat:
- No
- Area (mi²):
- 0.994
- State:
- Missouri
Knob Lick is a CDP located in St. Francois County, Missouri. Knob Lick has a 2025 population of 24. Knob Lick is currently growing at a rate of 9.09% annually and its population has decreased by 0% since the most recent census, which recorded a population of 24 in 2020.
The median age in Knob Lick is 45.1 years: 45.2 years for males, and 0 years for females.