Worthington
- County:
- Putnam County
- County Seat:
- No
- Area (mi²):
- 0.126
- State:
- Missouri
Worthington is a village located in Putnam County, Missouri. Worthington has a 2025 population of 58 . Worthington is currently declining at a rate of -3.33% annually and its population has decreased by -3.33% since the most recent census, which recorded a population of 60 in 2020.
The median age in Worthington is 59.5 years: 11.6 years for males, and 63.3 years for females. For every 100 females there are 130.0 males.