21 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Cambridge | Middlesex County | 123,057 |
| Chicopee | Hampden County | 55,415 |
| Chelsea | Suffolk County | 40,964 |
| Chelmsford | Middlesex County | 37,310 |
| Canton | Norfolk County | 25,525 |
| Concord | Middlesex County | 17,911 |
| Clinton | Worcester County | 15,845 |
| Charlton | Worcester County | 13,740 |
| Carver | Plymouth County | 11,907 |
| Cohasset | Norfolk County | 8,611 |
| Chatham | Barnstable County | 6,713 |
| Carlisle | Middlesex County | 5,386 |
| Cheshire | Berkshire County | 3,183 |
| Conway | Franklin County | 1,748 |
| Colrain | Franklin County | 1,658 |
| Clarksburg | Berkshire County | 1,632 |
| Chilmark | Dukes County | 1,261 |
| Chester | Hampden County | 1,227 |
| Charlemont | Franklin County | 1,178 |
| Chesterfield | Hampshire County | 1,169 |
| Cummington | Hampshire County | 815 |