52 cities
| City | State | 2025 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Atlanta | Georgia | 525,088 | 0.96% | 1 | City |
| New Orleans | Louisiana | 357,532 | -1.43% | 2 | City |
| Huntsville | Alabama | 233,907 | 1.52% | 3 | City |
| Baton Rouge | Louisiana | 219,565 | -0.61% | 4 | City |
| Augusta | Georgia | 201,663 | -0.04% | 5 | Township |
| Columbus | Georgia | 200,533 | -0.64% | 6 | City |
| Mobile | Alabama | 200,086 | -0.64% | 7 | City |
| Birmingham | Alabama | 195,378 | -0.5% | 8 | City |
| Montgomery | Alabama | 194,760 | -0.54% | 9 | City |
| Shreveport | Louisiana | 174,023 | -1.45% | 10 | City |
| Charleston | South Carolina | 159,315 | 1.05% | 11 | City |
| Macon-Bibb County | Georgia | 157,060 | 0% | 12 | Township |
| Savannah | Georgia | 149,136 | 0.22% | 13 | City |
| Columbia | South Carolina | 146,933 | 1.48% | 14 | City |
| Metairie | Louisiana | 140,437 | 0.09% | 15 | CDP |
| Jackson | Mississippi | 138,560 | -2.04% | 16 | City |
| Athens | Georgia | 129,054 | 0.28% | 17 | Township |
| North Charleston | South Carolina | 128,603 | 2.06% | 18 | City |
| Lafayette | Louisiana | 122,487 | 0.17% | 19 | City |
| Tuscaloosa | Alabama | 116,465 | 1.9% | 20 | City |
| South Fulton | Georgia | 112,943 | 0.84% | 21 | City |
| Sandy Springs | Georgia | 104,828 | -0.64% | 22 | City |
| Mount Pleasant | South Carolina | 96,692 | 1.14% | 23 | Town |
| Hoover | Alabama | 93,093 | 0.09% | 24 | City |
| Roswell | Georgia | 92,049 | -0.19% | 25 | City |
| Warner Robins | Georgia | 87,604 | 1.63% | 26 | City |
| Auburn | Alabama | 85,429 | 2% | 27 | City |
| Johns Creek | Georgia | 80,812 | -0.44% | 28 | City |
| Lake Charles | Louisiana | 80,225 | -1.15% | 29 | City |
| Mableton | Georgia | 78,614 | 85.4% | 30 | CDP |
| Mableton | Georgia | 78,614 | 85.4% | 31 | CDP |
| Mableton | Georgia | 78,614 | 0.38% | 32 | CDP |
| Mableton | Georgia | 78,614 | 0.38% | 33 | CDP |
| Rock Hill | South Carolina | 76,084 | 0.38% | 34 | City |
| Greenville | South Carolina | 75,106 | 0.99% | 35 | City |
| Gulfport | Mississippi | 75,056 | 0.58% | 36 | City |
| Dothan | Alabama | 71,786 | 0.19% | 37 | City |
| Alpharetta | Georgia | 67,602 | 0.49% | 38 | City |
| Albany | Georgia | 66,105 | -0.9% | 39 | City |
| Madison | Alabama | 65,708 | 2.62% | 40 | City |
| Kenner | Louisiana | 64,240 | -0.63% | 41 | City |
| Marietta | Georgia | 63,643 | 0.83% | 42 | City |
| Bossier City | Louisiana | 63,344 | 0.2% | 43 | City |
| Stonecrest | Georgia | 61,451 | 0.71% | 44 | City |
| Brookhaven | Georgia | 60,018 | 1.09% | 45 | City |
| Decatur | Alabama | 58,184 | 0.36% | 46 | City |
| Southaven | Mississippi | 58,154 | 1.15% | 47 | City |
| Smyrna | Georgia | 57,429 | 0.44% | 48 | City |
| Valdosta | Georgia | 55,727 | 0.11% | 49 | City |
| Summerville | South Carolina | 53,042 | 0.79% | 50 | Town |
| Dunwoody | Georgia | 51,844 | 0.09% | 51 | City |
| Goose Creek | South Carolina | 51,375 | 2.03% | 52 | City |
For this list, the Deep South Region is defined as the 5 states of Alabama, Georgia, Louisiana, Mississippi and South Carolina.