108 cities
| City | State | 2025 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Houston | Texas | 2,412,920 | 0.95% | 1 | City |
| San Antonio | Texas | 1,548,485 | 1.43% | 2 | City |
| Dallas | Texas | 1,331,752 | 0.43% | 3 | City |
| Fort Worth | Texas | 1,029,221 | 2.09% | 4 | City |
| Austin | Texas | 1,000,511 | 0.7% | 5 | City |
| Oklahoma City | Oklahoma | 720,377 | 1.05% | 6 | City |
| El Paso | Texas | 682,308 | 0.09% | 7 | City |
| Omaha | Nebraska | 488,385 | -0.18% | 8 | City |
| Tulsa | Oklahoma | 415,526 | 0.09% | 9 | City |
| Arlington | Texas | 405,995 | 0.58% | 10 | City |
| Wichita | Kansas | 401,722 | 0.18% | 11 | City |
| Corpus Christi | Texas | 317,075 | -0.08% | 12 | City |
| Lincoln | Nebraska | 302,814 | 0.73% | 13 | City |
| Plano | Texas | 295,002 | 0.59% | 14 | City |
| Lubbock | Texas | 275,595 | 1.29% | 15 | City |
| Laredo | Texas | 262,701 | 0.55% | 16 | City |
| Irving | Texas | 258,348 | 0.11% | 17 | City |
| Garland | Texas | 251,440 | 0.4% | 18 | City |
| Frisco | Texas | 243,319 | 3.45% | 19 | City |
| McKinney | Texas | 235,030 | 3.3% | 20 | City |
| Sioux Falls | South Dakota | 213,249 | 1.89% | 21 | City |
| Grand Prairie | Texas | 210,113 | 1.34% | 22 | City |
| Amarillo | Texas | 204,519 | 0.39% | 23 | City |
| Overland Park | Kansas | 204,153 | 0.62% | 24 | City |
| Brownsville | Texas | 193,296 | 0.69% | 25 | City |
| Denton | Texas | 172,215 | 3.75% | 26 | City |
| Killeen | Texas | 162,330 | 1.07% | 27 | City |
| Kansas City | Kansas | 156,864 | 0.07% | 28 | City |
| Olathe | Kansas | 150,903 | 1.25% | 29 | City |
| McAllen | Texas | 150,377 | 1.07% | 30 | City |
| Mesquite | Texas | 150,265 | 0.08% | 31 | City |
| Pasadena | Texas | 149,159 | -0.31% | 32 | City |
| Waco | Texas | 148,124 | 1.03% | 33 | City |
| Midland | Texas | 146,297 | 1.82% | 34 | City |
| Round Rock | Texas | 139,055 | 2.73% | 35 | City |
| Fargo | North Dakota | 138,859 | 1.89% | 36 | City |
| Lewisville | Texas | 138,371 | 1.76% | 37 | City |
| Carrollton | Texas | 135,929 | 0.35% | 38 | City |
| Abilene | Texas | 131,818 | 1.01% | 39 | City |
| Norman | Oklahoma | 131,717 | 0.54% | 40 | City |
| Pearland | Texas | 130,522 | 0.7% | 41 | City |
| College Station | Texas | 129,834 | 1.41% | 42 | City |
| Topeka | Kansas | 125,226 | -0.19% | 43 | City |
| Broken Arrow | Oklahoma | 124,956 | 1.79% | 44 | City |
| The Woodlands | Texas | 124,541 | 1.67% | 45 | CDP |
| New Braunfels | Texas | 122,675 | 5.32% | 46 | City |
| Odessa | Texas | 120,951 | 1% | 47 | City |
| Conroe | Texas | 120,417 | 5.09% | 48 | City |
| League City | Texas | 119,405 | 0.8% | 49 | City |
| Richardson | Texas | 117,949 | -0.23% | 50 | City |
| Allen | Texas | 115,793 | 1.8% | 51 | City |
| Tyler | Texas | 113,706 | 1.33% | 52 | City |
| Beaumont | Texas | 112,396 | -0.44% | 53 | City |
| Edinburg | Texas | 110,724 | 1.83% | 54 | City |
| Sugar Land | Texas | 109,602 | -0.23% | 55 | City |
| Georgetown | Texas | 109,502 | 8.05% | 56 | City |
| Wichita Falls | Texas | 102,344 | -0.03% | 57 | City |
| San Angelo | Texas | 100,182 | 0.02% | 58 | City |
| Edmond | Oklahoma | 100,112 | 1.08% | 59 | City |
| Temple | Texas | 99,634 | 3.5% | 60 | City |
| Lawrence | Kansas | 97,854 | 0.6% | 61 | City |
| Atascocita | Texas | 94,940 | 2.09% | 62 | CDP |
| Leander | Texas | 94,177 | 7.62% | 63 | City |
| Bryan | Texas | 93,336 | 1.96% | 64 | City |
| Lawton | Oklahoma | 89,940 | -0.1% | 65 | City |
| Mission | Texas | 89,251 | 0.76% | 66 | City |
| Baytown | Texas | 86,146 | 0.17% | 67 | City |
| Longview | Texas | 84,142 | 0.57% | 68 | City |
| Mansfield | Texas | 82,802 | 2.47% | 69 | City |
| Pharr | Texas | 81,466 | 0.4% | 70 | City |
| Rapid City | South Dakota | 81,131 | 1.55% | 71 | City |
| Flower Mound | Texas | 80,864 | 1.09% | 72 | Town |
| Missouri City | Texas | 79,617 | 1.32% | 73 | City |
| Bismarck | North Dakota | 78,779 | 1.29% | 74 | City |
| Cedar Park | Texas | 78,465 | 0.11% | 75 | City |
| San Marcos | Texas | 75,839 | 2.05% | 76 | City |
| Harlingen | Texas | 72,281 | 0.07% | 77 | City |
| North Richland Hills | Texas | 71,721 | 0.4% | 78 | City |
| Kyle | Texas | 70,683 | 7.37% | 79 | City |
| Shawnee | Kansas | 70,297 | 0.82% | 80 | City |
| Rowlett | Texas | 69,461 | 1.96% | 81 | City |
| Pflugerville | Texas | 67,151 | 0.5% | 82 | City |
| Spring | Texas | 66,338 | 1.23% | 83 | CDP |
| Victoria | Texas | 66,141 | 0.18% | 84 | City |
| Little Elm | Texas | 64,720 | 5.72% | 85 | City |
| Bellevue | Nebraska | 64,682 | -0.15% | 86 | City |
| Wylie | Texas | 64,221 | 2.01% | 87 | City |
| Moore | Oklahoma | 64,042 | 0.31% | 88 | City |
| Fulshear | Texas | 63,882 | 16.94% | 89 | City |
| Celina | Texas | 60,122 | 16.38% | 90 | City |
| Grand Forks | North Dakota | 60,019 | 0.29% | 91 | City |
| Lenexa | Kansas | 59,901 | 0.8% | 92 | City |
| Euless | Texas | 59,742 | -0.45% | 93 | City |
| Texas City | Texas | 59,272 | 2.41% | 94 | City |
| Midwest City | Oklahoma | 58,515 | 0.02% | 95 | City |
| Burleson | Texas | 58,316 | 3.67% | 96 | City |
| DeSoto | Texas | 56,879 | 0.3% | 97 | City |
| Port Arthur | Texas | 55,746 | -0.09% | 98 | City |
| Rockwall | Texas | 54,996 | 2.71% | 99 | City |
| Manhattan | Kansas | 54,837 | 0.25% | 100 | City |
| Galveston | Texas | 53,509 | -0.05% | 101 | City |
| Grand Island | Nebraska | 53,305 | 0.1% | 102 | City |
| Sherman | Texas | 51,796 | 3.12% | 103 | City |
| Grapevine | Texas | 51,458 | 0.27% | 104 | City |
| Stillwater | Oklahoma | 50,575 | 0.87% | 105 | City |
| Huntsville | Texas | 50,410 | 1.84% | 106 | City |
| Waxahachie | Texas | 50,366 | 3.6% | 107 | City |
| Enid | Oklahoma | 50,358 | -0.32% | 108 | City |
For this list, the Great Plains Region is defined as the 6 states of Kansas, Nebraska, North Dakota, Oklahoma, South Dakota and Texas.