18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| New Haven | 1 | 139,624 | 129,314 | 1.5% | 7,471 | 19 | City |
| Hamden | 2 | 61,609 | 60,736 | 0.16% | 1,888 | 33 | Township |
| Meriden | 3 | 60,905 | 60,622 | 0.09% | 2,566 | 24 | City |
| West Haven | 4 | 55,335 | 55,553 | -0.08% | 5,147 | 11 | City |
| Milford | 5 | 51,152 | 50,411 | 0.29% | 2,335 | 22 | Township |
| Wallingford | 6 | 44,520 | 44,533 | 0.3% | 1,137 | 39 | Township |
| Branford | 7 | 28,669 | 28,132 | 0.78% | 1,313 | 22 | Township |
| East Haven | 8 | 28,172 | 27,832 | 0.78% | 2,291 | 12 | Township |
| East Haven | 9 | 27,524 | 28,645 | -0.42% | 2,238 | 12 | CDP |
| North Haven | 10 | 25,271 | 24,129 | 1.72% | 1,213 | 21 | Township |
| North Haven | 11 | 24,201 | 23,665 | 0.03% | 1,161 | 21 | CDP |
| Guilford | 12 | 22,375 | 22,021 | 0.5% | 475 | 47 | Township |
| Madison | 13 | 17,793 | 17,618 | 0.59% | 492 | 36 | Township |
| Orange | 14 | 14,462 | 14,229 | 0.21% | 842 | 17 | Township |
| Orange | 15 | 14,300 | 13,928 | 0.16% | 832 | 17 | CDP |
| North Branford | 16 | 13,602 | 13,504 | 0.38% | 549 | 25 | Township |
| Woodbridge | 17 | 9,197 | 9,057 | 0.73% | 489 | 19 | Township |
| Bethany | 18 | 5,348 | 5,281 | 0.45% | 254 | 21 | Township |
New Haven is the largest city in South Central CT Planning Region, with a population of 139,624.
Bethany is the smallest city in South Central CT Planning Region, with a population of 5,348.
There are 18 cities in South Central CT Planning Region, Connecticut.