11 ZIP Codes
| Zip Code | City | Population ↓ |
|---|---|---|
| 29488 | Walterboro | 22,538 |
| 29435 | Cottageville | 4,304 |
| 29945 | Yemassee | 3,918 |
| 29475 | Ruffin | 2,286 |
| 29481 | Smoaks | 1,759 |
| 29474 | Round O | 1,420 |
| 29929 | Islandton | 1,276 |
| 29446 | Green Pond | 1,184 |
| 29082 | Lodge | 371 |
| 29452 | Jacksonboro | 318 |
| 29493 | Williams | 156 |
The data shown reflect ZCTAs from the US Census. As of 2025, there are 11 ZCTAs in Colleton County, South Carolina (US Census).