Upstate South Carolina Cities

City
Rank
County
2026 Pop.↓
Greenville1Greenville County76,180
Greer2Greenville County52,676
Spartanburg3Spartanburg County40,261
Mauldin4Greenville County32,739
Anderson5Anderson County31,715
Simpsonville6Greenville County29,612
Easley7Pickens County28,302
Taylors8Greenville County24,163
Greenwood9Greenwood County22,796
Wade Hampton10Greenville County20,722
Five Forks11Greenville County20,236
Clemson12Pickens County19,149
Fountain Inn13Greenville County15,551
Gantt14Greenville County15,248
Powdersville15Anderson County13,934
Boiling Springs16Spartanburg County13,622
Parker17Greenville County12,825
Gaffney18Cherokee County12,538
Seneca19Oconee County9,515
Travelers Rest20Greenville County9,428
Laurens21Laurens County9,326
Sans Souci22Greenville County8,275
Union23Union County8,033
Clinton24Laurens County7,972
Clemson University25Anderson County7,919
Welcome26Anderson County7,617
Valley Falls27Spartanburg County7,468
Lyman28Spartanburg County7,296
Homeland Park29Anderson County7,094
Centerville30Anderson County6,923
Woodruff31Spartanburg County6,237
Piedmont32Greenville County5,944
Central33Pickens County5,309
Abbeville34Abbeville County4,910
Duncan35Spartanburg County4,802
Belton36Anderson County4,692
Whitney37Spartanburg County4,503
Williamston38Anderson County4,396
Walhalla39Oconee County4,366
Saxon40Spartanburg County4,304
Keowee Key41Oconee County4,070
Southern Shops42Spartanburg County4,035
Wellford43Spartanburg County4,020
Honea Path44Anderson County4,003
Northlake45Anderson County3,872
Pendleton46Anderson County3,790
Hilltop47Spartanburg County3,764
Roebuck48Spartanburg County3,761
Dunean49Greenville County3,726
Arkwright50Spartanburg County3,582
Inman51Spartanburg County3,550
Liberty52Pickens County3,336
Golden Grove53Anderson County3,226
Pickens54Pickens County3,194
East Gaffney55Cherokee County3,188
Landrum56Spartanburg County2,942
Ben Avon57Spartanburg County2,873
Arcadia58Spartanburg County2,745
Pacolet59Spartanburg County2,715
Westminster60Oconee County2,528
Watts Mills61Laurens County2,392
Cowpens62Spartanburg County2,309
Judson63Greenville County2,236
Tigerville64Greenville County2,103
Ninety Six65Greenwood County2,092
Mayo66Spartanburg County2,049
Blacksburg67Cherokee County1,982
Camp Croft68Spartanburg County1,974
Reidville69Spartanburg County1,958
Arial70Pickens County1,904
Slater-Marietta71Greenville County1,878
Monarch Mill72Union County1,832
Calhoun Falls73Abbeville County1,788
Ware Shoals74Greenwood County1,739
Fairforest75Spartanburg County1,715
Utica76Oconee County1,538
Pelzer77Anderson County1,453
Conestee78Greenville County1,446
Joanna79Laurens County1,337
Due West80Abbeville County1,315
Drayton81Spartanburg County1,284
Lake Secession82Abbeville County1,238
Iva83Anderson County1,225
Buffalo84Union County1,224
Cateechee85Anderson County1,216
Sandy Springs86Anderson County1,175
City View87Greenville County1,132
La France88Anderson County1,126
West Pelzer89Anderson County1,052
The Cliffs Valley90Greenville County1,001
Chesnee91Spartanburg County984
Clifton92Spartanburg County935
Chickasaw Point93Anderson County898
Inman Mills94Spartanburg County860
Gray Court95Laurens County819
Jonesville96Union County810
Campobello97Spartanburg County803
Six Mile98Pickens County771
Norris99Pickens County762
Modoc100McCormick County659
Fair Play101Oconee County553
Cross Hill102Laurens County445
Newry103Oconee County444
Enoree104Spartanburg County427
South Union105Anderson County410
West Union106Oconee County399
Converse107Spartanburg County382
Cokesbury108Abbeville County370
Lockhart109Union County366
Mount Carmel110McCormick County366
Carlisle111Union County319
Donalds112Abbeville County318
Startex113Spartanburg County315
Pauline114Spartanburg County314
Antreville115Abbeville County279
Dacusville116Pickens County266
Fingerville117Spartanburg County262
Central Pacolet118Cherokee County253
Bradley119Greenwood County216
Glenn Springs120Spartanburg County213
Starr121Anderson County182
Hodges122Greenwood County161
Waterloo123Laurens County160
Glendale124Spartanburg County142
Parksville125McCormick County133
Salem126Oconee County130
Lowndesville127Abbeville County121
Gramling128Spartanburg County110
Princeton129Abbeville County108
Mountville130Laurens County98
Troy131Greenwood County87
Tamassee132Oconee County82
Cross Anchor133Spartanburg County80
Plum Branch134McCormick County80
Ware Place135Anderson County72
Clarks Hill136McCormick County66
Caesars Head137Greenville County46
Promised Land138Abbeville County38
Cherokee Falls139Cherokee County34
Longcreek140Oconee County32
Coronaca141Abbeville County13

About Upstate South Carolina

Sources

  1. US Census: 2025 Gazetteer Files
  2. City and Town Population Totals: 2020-2024